Comparison of the therapeutic efficacy of oral doses of fluconazole and griseofulvin in a guinea pig model of dermatophytosis.

Methods for the susceptibility test of yeast to antifungal agents have been standardized by the National Committee for Clinical Laboratory Standards7), while the standard method has not yet been established for the filamentous fungi. Furthermore, the in vitro activity of azole antifungal agents is known to be affected by various assay conditions8^12). For these reasons, measuring the in vivo activity of azole antifungal agents in suitable animal models is essential for predicting the clinical efficacy of those agents against mycoses caused by filamentous fungi. In the present study, the therapeutic efficacy of orally administered FLCZwas studied in a guinea pig model of tinea corporis that has been successfully used in our laboratory for evaluating the in vivo activity of several antifungal agents on dermatophytes13~16). Griseofulvin